SMAD1

(redirected from SMAD family member 1)

SMAD1

A gene on chromosome 4q31.21 that encodes a SMAD family protein, named for their similarity to the Drosophila gene Mothers Against Decapentaplegic (Mad), which are signal transducers and transcription modulators of multiple signalling pathways. SMAD1 mediates signals from bone morphogenetic proteins (BMPs), which mediate an array of biological activities, including cell growth, apoptosis, morphogenesis, development and immune responses. In response to the binding of BMP ligands, SMAD is phosphorylated and activated by the BMP receptor kinase; phosphorylated SMAD1 forms a complex with SMAD4, resulting in transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases—SMURF1 and SMURF2. Its activity is downregulated by ubiquitination and proteasome-mediated degradation.
References in periodicals archive ?
B binding protein Transforming growth factor, beta 2 TCFBR2 Transforming growth factor, beta receptor II TCF/Smad pathway SMAD1 SMAD family member 1 SMAD6 SMAD family member 6 S0X4 SRY (sex determining region Y)-box 4 SP1 Spl transcription factor CTNNB1 CREB binding protein Ras/MAPK(non-Smad) RHOA Ras homolog gene family, pathway member A RH08 Ras homolog gene family, member B MAP3K7 Mitogen-activated protein kinase kinase kinase 7 MAPK14 Mitogen-activated protein kinase 14 Downstream effector BCL2L1 BCL2-like 1 CDC6 Cell division cycle 6 homolog CDKN1B Cyclin-dependent kinase inhibitor 1B CEBPB CCAAT/enhancer binding protein (C/EBP), beta FN1 Fibronectin 1 CADD45B Growth arrest and DNA-damage-inducible.