After showing that blocking SMAD
signaling could prevent the differentiation of airway stem cells from mice, they found that blocking both TGF-[beta] and BMP pathways allowed the expansion of many generations of airway stem cells.
The results provide some clues as to how SMADs
might selectively bind to one set of target genes in stem cells and another in its progeny, but there is much left to learn about how the sequential process of target gene selection and differentiation is controlled and how it changes along the path to tissue production.
FOR IT King's strapping grey ticks all the boxes in a typically tough Hennessy.
ABOUT THE BOY Newsboy tipped Hennessy winner Smad Place (7-1)
PLACE has the right spirit to lift the Hennessy Gold Cup (3.
PLACE (Alan King) has twice been placed in the World Hurdle.
PLACE, one of last season's best staying novice chasers, will make his seasonal bow in the Hennessy at Newbury later this month after pleasing Alan King this summer.
The RSA has thrown up some excellent chasers recently and I'm hoping Alan King's SMAD
50, CH4), so take the hint and side with bottom weight SMAD
VVSMAD spot-on for King SMAD
PLACE was down to a best-priced 9-2 yesterday for the inaugural BetBright Cup at Cheltenham on Saturday, with Alan King convinced he can improve on his fifth in the Hennessy.
Earlier studies have shown that the Smads go through chemical changes.
A number of earlier studies performed by Massague's lab had identified that Smads undergo phosphorylations -a kind of chemical change - in a region of the protein about which little is known.