LCP2

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LCP2

A gene on chromosome 5q33.1-qter that encodes lymphocyte cytosolic protein 2/SLP76, which acts as an adaptor or scaffold protein, and may play a role in T-cell development and activation and in mast cell and platelet function.

Molecular pathology
L-plastin has been found in many types of non-haemopoietic malignant cells, suggesting that its expression is linked to tumourigenesis in solid tissues.
References in periodicals archive ?
Written and edited by experts in the field this volume includes 17 contributions covering ITAM-mediated signaling by the T-cell antigen receptor, ZAP-70 as an essential kinase in T-cell signaling, the coordination of receptor signaling in multiple hematopoietic cell lineages by the adapter protein SLP-76, an enigmatic tail of CD28 signaling, lipid signaling in T-cell development and function, the mediation of T-cell activation by actin meshworks, understanding the structure and function of the immunological synapse, and perspectives for computer modeling in the study of T-cell activation.