SLCO1B3

SLCO1B3

A gene on chromosome 12p12 that encodes a transporter which mediates Na+-independent uptake of organic anions—e.g., oestradiol, taurocholate, triiodothyronine, leukotriene C4, dehydroepiandrosterone sulfate, methotrexate and sulfobromophthalein.
 
Molecular pathology
Defects in SLCO1B3 are a cause of Rotor syndrome.
References in periodicals archive ?
However, the association was found in SNPs of another gene in the same gene family, SLCO1B3 (rs2117032, P = 4.
In addition, the effects of SLCO1B1 or other transporter genes within the same chromosome location such as SLCO1B3, as well as X-linked G6PD, were confirmed.
Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).