SLCO1B1

SLCO1B1

A gene on chromosome 12p12 that encodes a transporter which mediates Na+-independent uptake of organic anions—e.g., pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl oestradiol, oestrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. SLCO1B1 may play a key role in clearing bile acids and organic anions from the liver.

Molecular pathology
Defects in SLCO1B1 are a cause of Rotor syndrome.
References in periodicals archive ?
The best-studied genetic contributor to statin-induced side effects is SLCO1B1 (also referred to as SLC21A6, OATP-C, or OATP1B1), which codes for a hepatic drug transporter that mediates the hepatic uptake of statins.
The relevant factor is a genetic combination known as the SLCO1B1 polymorphism, (12) specifically the variant c.
PA), the global leader in bio-analytical testing, and one of the world leaders in genomic services, announces the launch ofStatinSmart, the first and only at-home saliva laboratory developed test that analyzes the SLCO1B1 (Solute Carrier Organic Anion Transporter 1B1) gene for a variant known to increase an individual's risk for developing statin induced myopathy - the onset of muscle aches, spasms and pain associated with statin therapy.
Regarding the statin adverse effects, the pharmacogenomic association of greatest magnitude found so far is between SLCO1B1 non-synonymous SNP polymorphism rs4149056 and statin-induced muscle toxicity (521C>T, Val174Ala amino-acid change from valine to alanine, defining SLCO1B1*5 variant).
CYP3A5, ABCB1 and SLCO1B1 Polymorphisms and Pharmacokinetics and Virologic Outcome of Lopinavir/Ritonavir in HIV-infected Children.
SEARCH Collaborative Group, SLCO1B1 Variants and Statin Induced Myopathy--A Genomewide Study, 359 NEW ENG.
Still, the findings suggest that it may be beneficial to be cautious about using a statin in patients known to have the SLCO1B1 variant and that this type of testing may enter practice if additional data support these early findings.
They found a strong association of myopathy with single-nucleotide polymorphism located within the SLCO1B1 gene.
As the role of SLCO1B1 gene (encodes OATP1B1 or liver specific transporter-1) 388 A>G polymorphism in susceptibility towards gallstone disease is unclear the prevalence of this polymorphism in healthy north Indian population was investigated.
A variant form of the gene SLCO1B1 may be responsible for muscle pain that statins sometimes cause (SN: 8/16/08, p.
The gene, called SLCO1B1, encodes a protein that shuttles compounds from the blood stream into the liver for processing.
These are related to the SLCO1B1 polymorphism, (27) which has significant effects on the pharmacokinetics of different statins.