SLCO1B1

SLCO1B1

A gene on chromosome 12p12 that encodes a transporter which mediates Na+-independent uptake of organic anions—e.g., pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl oestradiol, oestrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. SLCO1B1 may play a key role in clearing bile acids and organic anions from the liver.

Molecular pathology
Defects in SLCO1B1 are a cause of Rotor syndrome.
References in periodicals archive ?
PA), the global leader in bio-analytical testing, and one of the world leaders in genomic services, announces the launch ofStatinSmart, the first and only at-home saliva laboratory developed test that analyzes the SLCO1B1 (Solute Carrier Organic Anion Transporter 1B1) gene for a variant known to increase an individual's risk for developing statin induced myopathy - the onset of muscle aches, spasms and pain associated with statin therapy.
19, 2015 /PRNewswire/ -- Boston Heart Diagnostics today announced the launch of StatinSmart(TM), the first and only at-home saliva laboratory developed test that analyzes the SLCO1B1 (Solute Carrier Organic Anion Transporter 1B1) gene for a variant known to increase an individual's risk for developing statin induced myopathy-the onset of muscle aches, spasms and pain associated with statin therapy.
One association--between statin-induced myopathy and SLCO1B1 (solute carrier organic anion transporter family, member 1B1)--involved several drugs (pravastatin, atorvastatin, and simvastatin) from a single class.
SEARCH Collaborative Group, SLCO1B1 Variants and Statin Induced Myopathy--A Genomewide Study, 359 NEW ENG.
Still, the findings suggest that it may be beneficial to be cautious about using a statin in patients known to have the SLCO1B1 variant and that this type of testing may enter practice if additional data support these early findings.
They found a strong association of myopathy with single-nucleotide polymorphism located within the SLCO1B1 gene.
As the role of SLCO1B1 gene (encodes OATP1B1 or liver specific transporter-1) 388 A>G polymorphism in susceptibility towards gallstone disease is unclear the prevalence of this polymorphism in healthy north Indian population was investigated.
A variant form of the gene SLCO1B1 may be responsible for muscle pain that statins sometimes cause (SN: 8/16/08, p.
The gene, called SLCO1B1, encodes a protein that shuttles compounds from the blood stream into the liver for processing.
PRODUCT INTRODUCTIONS/INNOVATIONS II-48CODIX Introduces SelexOn(TM) II-48Health Canada Approves Abbott's ARCHITECT STAT High SensitiveTroponin-I Assay II-48PTS Unveils CardioChek Plus II-48ACON Introduces Mission Systems II-48Everist Genomics to Unveil AngioDefender II-48Pathway Genomics Introduces InsightSM II-48Boston Heart Diagnostics Unveils SLCO1B1 Genotype Test II-48diaDexus Unveils PLAC Test in Europe II-48
A recent GWAS comparing 85 individuals with statin-induced myopathy with control individuals taking the same medication identified a common risk-factor SNP in the SLCO1B1 (solute carrier organic anion transporter family, member 1B1) gene, which encodes a transmembrane transporter already known to regulate intracellular statin concentrations (63).
PRODUCT INTRODUCTIONS/INNOVATIONS II-48 CODIX Introduces SelexOn(TM) II-48 Health Canada Approves Abbott's ARCHITECT STAT High Sensitive Troponin-I Assay II-48 PTS Unveils CardioChek Plus II-48 ACON Introduces Mission Systems II-48 Everist Genomics to Unveil AngioDefender II-48 Pathway Genomics Introduces InsightSM II-48 Boston Heart Diagnostics Unveils SLCO1B1 Genotype Test II-48 diaDexus Unveils PLAC Test in Europe II-48 9.