SLC45A2

SLC45A2

A gene on chromosome 5p13.2 that encodes solute carrier family 45, member 2, which is a melanocyte differentiation antigen thought to transport substances required for melanin biosynthesis. It is expressed in most melanoma cell lines and melanocytes.

Molecular pathology
SLC45A2 mutation causes oculocutaneous albinism type 4.
References in periodicals archive ?
Until recently, genetic studies have reported seven causative genes (TYR, TYRP1, OCA2, SLC45A2, SLC24A2, C10ORF11 and MCIR) and an uncharacterized OCA5 locus.
Until now, seven genes (TYR, TYRP1, OCA2, SLC45A2, SLC24A2, C10ORF11 and MC1R) and an uncharacterized OCA5 locus have been mapped on the human genome.
Various genetic studies to date identified six genes (TYR TYRP1 OCA2 SLC45A2 SLC24A5 C10orf11) and a locus (OCA5) for whom the candidate gene is yet to be known.
Key words: Oculocutaneous albinism melanin TYR TYRP1 OCA2 SLC45A2 SLC24A5 MC1R.
Mutations in SLC45A2 cause plumage color variation in chicken and Japanese quail.
MC1R, SLC45A2 and TYR genetic variants involved in melanoma susceptibility in Southern European populations: Results from a Meta-analysis.
The Spanish researchers sequenced the entire genome of snowflake and found a particular gene known as SLC45A2 as the cause behind the primate's albinism.
Researchers found that Snowflake inherited a mutant form of this SLC45A2 gene from both of his parents, who were closely related to each other, (http://www.
Those genetic analyses led them to a pigment gene, called SLC45A2, which had already been associated with light coloration in modern Europeans and in other animals, including horses, chickens, and fish.
9p23 lokusundaki TYRP1 (tyrosinase-related protein 1) genindeki mutasyon sonucu gorulen OCA3 (tip 3) ve 5p'deki SLC45A2 (eski adiyla MATP) geninde resesif ozellikte mutasyon sonucu gorulen OCA4 nadir okulokutanoz albinizm tipleridir.
The team then confirmed that the SLC45A2 mutation results in a white coat by scrutinizing 130 other unrelated tigers, both orange and white.
In horses, SLC45A2 is known as the "cream gene," and mutations can result in a range of lighter horse coat colors, from the tanner palomino: