SLCO1B1

(redirected from SLC21A6)

SLCO1B1

A gene on chromosome 12p12 that encodes a transporter which mediates Na+-independent uptake of organic anions—e.g., pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl oestradiol, oestrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. SLCO1B1 may play a key role in clearing bile acids and organic anions from the liver.

Molecular pathology
Defects in SLCO1B1 are a cause of Rotor syndrome.