SIX6

SIX6

A gene on chromosome 14q23.1 that encodes a member of the sine oculis homeobox (SIX) transcription factor family which plays a role in eye development.

Molecular pathology
SIX6 mutations may cause microphthalmia with cataract type 2 (MCOPCT2).
References in periodicals archive ?
They found that the expression of a variant of SIX6 and elevated intraocular pressure promote glaucoma by boosting p16INK4a, leading to the eventual demise of retinal ganglion cells.
To achieve this combination of technical sensitivity and specificity, we optimized qPCR assays selected from the tissue studies that used the HM technology [TUSC3, tumor suppressor candidate 3; TMEFF2; ZDHHC22, zinc finger, DHHC-type containing 22; VTN; FOXL2, forkhead box L2; NGFR; ALX4, aristaless-like homeobox 4; SIX6, SIX homeobox 6; EYA4; and SEPT9] (14).