Early in human development, we depend on a transcription factor called SIX1 to create this weed-like growth and nimble movement.
Many breast cancers wake SIX1, and the Oncogene paper details how SIX1 flips the TGF-beta signalling switch from tumor-suppressing or tumor-promoting.
SIX1 creates small molecules called microRNAs that regulate gene activity.
Turning on SIX1 and its associated microRNAs is like removing the speed governor from a reckless teenager's Mustang convertible.
High SIX1 or high microRNAs associated with SIX1 are a sign that a breast cancer is using TGF-beta signaling in a tumor-promoting way," Ford said.
Selected Examples of Genes in Which Mutations can Result in Various Congenital Abnormalities of the Kidney and Urinary Tract (CAKUT) Lesions CAKUT PAX2 TCF2 EYA1 SIX1
SALL1 Dysplasia X XX XX Agenesis X X Hypoplasia X X X UPJ obst X X X VU reflux X GCKD X Syndrome Renal-coloboma MODY5 BOR BOR Townes-Brock CAKUT GATA3 Dysplasia X Agenesis X Hypoplasia UPJ obst VU reflux X GCKD Syndrome HDR Abbreviations: BOR, branchial-oto-renal syndrome; GCKD, glomerulocystic kidney disease; HDR, hypoparathyroidism, deafness and renal dyspla- sia; MODY, maturity onset diabetes type 5; UPJ obst, ureteropelvic junction obstruction; VU, vesicoureteral.
Who set a new world ransfer record for a teenager of pounds 20 million in 2004SPORTING SIX1
From which club did Julian Dicks join Liverpool SPORTING SIX1
Cluster 1 genes (ZBTB1, PML, ZNF44, SIX1, BCL6, ZNF450) were down-regulated by V and involved in gene transcription, whereas cluster 2 genes (IL8, IL1A, PTGS2, DTR, TNFAIP3, CXCL3) were up-regulated and linked to inflammatory response and cell proliferation.
Cluster 1 contained ZBTB1, PML, ZNF44, SIX1, BCL6, and ZNF450 that were down-regulated by V and involved in gene transcription.
SIX1 encodes a protein characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved in determining DNA-binding specificity and protein-protein interactions.
Cloning of the human SIX1 gene and its assignment to chromosome 14.