SIX1

SIX1

A gene on chromosome 14q23.1 that encodes a homeobox protein similar to the Drosophila “sine oculis” gene product and thought to be involved in limb development.

Molecular pathology
SIX1 mutations are linked to autosomal dominant deafness type 23 and branchiootic syndrome type 3.
References in periodicals archive ?
PAX3 and SIX1 expression by immunohistochemistry (43) and gene-expression analysis (44) has recently been identified in borderline and malignant PTs and correlates with a poor clinical outcome.
Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32.
Early in human development, we depend on a transcription factor called SIX1 to create this weed-like growth and nimble movement.
Many breast cancers wake SIX1, and the Oncogene paper details how SIX1 flips the TGF-beta signalling switch from tumor-suppressing or tumor-promoting.
SIX1 creates small molecules called microRNAs that regulate gene activity.
Turning on SIX1 and its associated microRNAs is like removing the speed governor from a reckless teenager's Mustang convertible.
Who set a new world ransfer record for a teenager of pounds 20 million in 2004SPORTING SIX1.
From which club did Julian Dicks join Liverpool SPORTING SIX1.
Cluster 1 genes (ZBTB1, PML, ZNF44, SIX1, BCL6, ZNF450) were down-regulated by V and involved in gene transcription, whereas cluster 2 genes (IL8, IL1A, PTGS2, DTR, TNFAIP3, CXCL3) were up-regulated and linked to inflammatory response and cell proliferation.
Cluster 1 contained ZBTB1, PML, ZNF44, SIX1, BCL6, and ZNF450 that were down-regulated by V and involved in gene transcription.
SIX1 encodes a protein characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved in determining DNA-binding specificity and protein-protein interactions.
Selected Examples of Genes in Which Mutations can Result in Various Congenital Abnormalities of the Kidney and Urinary Tract (CAKUT) Lesions CAKUT PAX2 TCF2 EYA1 SIX1 SALL1 Dysplasia X XX XX Agenesis X X Hypoplasia X X X UPJ obst X X X VU reflux X GCKD X Syndrome Renal-coloboma MODY5 BOR BOR Townes-Brock CAKUT GATA3 Dysplasia X Agenesis X Hypoplasia UPJ obst VU reflux X GCKD Syndrome HDR Abbreviations: BOR, branchial-oto-renal syndrome; GCKD, glomerulocystic kidney disease; HDR, hypoparathyroidism, deafness and renal dyspla- sia; MODY, maturity onset diabetes type 5; UPJ obst, ureteropelvic junction obstruction; VU, vesicoureteral.