SIX1

(redirected from SIX homeobox 1)

SIX1

A gene on chromosome 14q23.1 that encodes a homeobox protein similar to the Drosophila “sine oculis” gene product and thought to be involved in limb development.

Molecular pathology
SIX1 mutations are linked to autosomal dominant deafness type 23 and branchiootic syndrome type 3.
References in periodicals archive ?
18) On a molecular basis, the conversion of metanephric parenchyma to nephron epithelia requires many transcriptional factors, including WT1; eyes absent homolog 1 (EYA1); forkhead box C1 (FOXC1); PAX2; PAX8; growth differentiation factor 11 (GDF11); sal-like 1 (SALL1); SIX homeobox 1 (SIX1); wingless-type MMTV integration site family, member 4 (WNT4); and GATA binding protein 3 (GATA3) (6,7) These genes and their encoded proteins interact to form a network rather than a linear and hierarchic pathway.