SIRT4


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SIRT4

A gene on chromosome 12q24.31 that encodes an NAD-dependent protein ADP-ribosyl transferase that catalyses the transfer of ADP-ribosyl groups onto target proteins (e.g., mitochondrial GLUD1), inhibiting its enzyme activity. SIRT4 interacts with GLUD1, IDE and SLC25A5, is widely expressed, especially in vascular smooth muscle, striated muscle and in beta-cells in pancreas islets; it downregulates insulin secretion.
References in periodicals archive ?
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
This study shows for the first time that activation of SIRT3 and SIRT4, members of the sirtuin family of enzymes, protects against cell damage.
This study identifies SIRT3 and SIRT4 as additional targets, expanding beyond previous work which focused on targeting SIRT1.
The rise in Nampt requires an intact mitochondrial NAD(+) salvage pathway as well as the mitochondrial NAD(+)-dependent deacetylases SIRT3 and SIRT4.
Fasting increases the level of NAD and both SIRT3 and SIRT4 also control metabolism, so this discovery further explains how fasting affects cell survival and alters our metabolism by triggering these sirtuins.