SIRT4


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SIRT4

A gene on chromosome 12q24.31 that encodes an NAD-dependent protein ADP-ribosyl transferase that catalyses the transfer of ADP-ribosyl groups onto target proteins (e.g., mitochondrial GLUD1), inhibiting its enzyme activity. SIRT4 interacts with GLUD1, IDE and SLC25A5, is widely expressed, especially in vascular smooth muscle, striated muscle and in beta-cells in pancreas islets; it downregulates insulin secretion.
References in periodicals archive ?
As discussed above, other Sirtuins, especially, SIRT4 is also a mitochondrial deacetylase as SIRT3 and functions as tumor suppressor via modulating glutamine metabolism.
We suspect additional signaling pathways or modulating factors may exist among these Sirtuins with further studies, especially for the lesser studied SIRT4, SIRT5 and SIRT7.
Glutamate dehydrogenase 1 and SIRT4 regulate glial development.
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase," Journal of Biological Chemistry, vol.
Recent findings clarify the protective effect of Sirt4 against cell death induced by genotoxic stress.
The mitochondrial deacetylases SIRT3 and SIRT4 have been shown to contrast the EMT activation through metabolic reprogramming.
On the other hand, SIRT7 has been related to EMT induction only, while SIRT3 and SIRT4 have been described as pure EMT repressors.