SIRT2

SIRT2

A gene on chromosome 19q13 that encodes a widely expressed NAD-dependent enzyme that deacetylates Lys-40 of alpha-tubulin and is involved in controlling mitotic exit in the cell cycle, possibly by cytoskeletal regulation.
References in periodicals archive ?
Many studies have shown that an extra copy of SIRT2 genes improved life expectancy by 50 percent, while its deletion lowered longevity.
The seven known sirtuins in mammals are identified by number: SIRT1, SIRT2 .
The new study by investigators at Vanderbilt-Ingram Cancer Centre and the National Institutes of Health (NIH) identifies the protein SIRT2 as a tumour suppressor linked to gender-specific tumour development in mice.
and colleagues at the NIH's National Institute of Diabetes and Digestive and Kidney Diseases - investigated the physiological functions of SIRT2 by eliminating the protein in cultured cells and in mice.
Lack of SIRT2 in female mice led to mammary (breast) tumours, while male mice lacking SIRT2 developed a range of gastrointestinal tumours (in the liver, pancreas, colon and stomach).
Laboratory tests showed that blocking the action of a brain protein called SIRT2 may help prevent damage to neurons.
The new research, published in the journal Science, identified a biological pathway linked to alpha-synuclein involving the biological catalyst SIRT2.
Experiments on cultured rat neurons and fruit flies with a version of Parkinson's showed that a particular compound could be used to block SIRT2 activity and reduce alpha-synuclein's toxic effects.
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
5,8-10) In the Harvard study, resveratrol helped counteract changes in SIRT2 expression induced by a high-calorie diet.