SIRT1


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Related to SIRT1: SIRT2

SIRT1

A gene on chromosome 10q21.3 that encodes a widely expressed NAD-dependent protein deacetylase, which links transcriptional regulation to intracellular energetics and co-ordinates distinct cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. SIRT1 can modulate chromatin function by deacetylating histones and altering the methylation of histones and DNA, leading to transcriptional repression. It deacetylates a broad range of transcription factors and co-regulators, up- and downregulating target gene expression.
References in periodicals archive ?
Studies in primitive animals demonstrate that AMPK slows aging by modulating expression of critical transcription factors and enzymes, as would be expected by its effects on SIRT1.
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages.
Their past work on the hypothalamus also had shown that SIRT1 function is dependent on energy levels in cells.
The team's experiments showed, however, that the TyrRS-PARP-1 pathway can be measurably activated by much lower doses of resveratrol-as much as 1,000 times lower-than were used in some of the more celebrated prior studies, including those focused on SIRT1.
SRT1720 activates SIRT1 apparently without affecting other proteins.
Also, drugs that increase SIRT1 activity have been found to slow the onset of aging and delay age-associated diseases in several animal models.
Experiments on cultivated mouse cells in the laboratory confirmed that metformin has a direct effect on the vascular function through interaction with a protein called sirtuin 1, which is encoded by the SIRT1 gene, known to play a role in ageing.
Several companies, including one cofounded by Sinclair, are developing drugs to activate SIRT1.
SIRT1 is the founding member and the most widely studied of the sirtuins (SIRT 1-7), a family of enzymes that appear to control various aspects of aging and disease.
At the conference Haim Cohen, PhD, Bar-Ilan University, Faculty of Life Sciences, Israel, reported on his work comparing the effects of SIRT1 and SIRT6.
The group not only confirmed that caloric restriction delays nerve cell loss, but also found that a drug that activates SIRT1 produces the same effects.
Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors Foxos and SIRT1.