SIRPA

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SIRPA

A gene on chromosome 20p13 that encodes a ubiquitous immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment, and may play a key role in intracellular signalling during synaptogenesis and in synaptic function. It downregulates receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors and insulin; it also downregulates phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. It is highly expressed in the brain.
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The conceptual basis for SIRP rests on common approaches to knowledge transfer, the spheres of influence approach, in order to highlight the importance of the transfer of policy research knowledge.
The SIRP model speaks to the linkages between policy researchers and research users illustrated through successive layers of influence.
It is worth noting that, like the payback framework, SIRP aligns multiple spheres with multiple impact categories.
To this end, we compared a prevalent model of research impact assessment and proposed an alternative model for social science research in government in the SIRP.
Though we propose SIRP as a better alternative, there are undoubtedly advantages for government departments to shorten implementation through the adaptation of an existing PM approach.
4) As the SIRP model was developed conceptually specifically for ESDC.