SIADH

SIADH syndrome of inappropriate antidiuretic hormone.

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SIADH,

abbreviation for syndrome of inappropriate antidiuretic hormone secretion.

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syndrome [sin´drōm]

a combination of symptoms resulting from a single cause or so commonly occurring together as to constitute a distinct clinical picture. For specific syndromes, see under the name, such as adrenogenital syndrome or reye's syndrome. See also disease and sickness.

syndrome of crocodile tears spontaneous lacrimation occurring parallel with the normal salivation of eating. It follows facial paralysis and seems to be due to straying of the regenerating nerve fibers, some of those destined for the salivary glands going to the lacrimal glands.

syndrome of inappropriate antidiuretic hormone (SIADH) a syndrome in which secretion of vasopressin (antidiuretic hormone) is not inhibited by hypotonicity of extracellular fluid and hyponatremia is produced. It occurs in conjunction with oat cell carcinoma of the lung and certain other malignant tumors and is caused by production of vasopressin by the tumor. See also ectopic hormones.

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SIADH

syndrome of inappropriate secretion of antidiuretic hormone.

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SIADH

Syndrome of inappropriate antidiuretic hormone secretion, dilutional hyponatremia A complex characterized by ↑ vasopressin–ADH secretion despite low plasma osmolarity, water retention, dilutional hyponatremia Etiology Addison's disease, ACTH deficiency, AIDS, hypopituitarism, ectopic hormone production in CA–small cell, bronchogenic, pancreas, uterine, bladder, prostate, lymphoproliferative disorders, mesothelioma, thymoma, CNS disease–trauma, infection, chromophobe adenoma, metastases, lung disease–TB, pneumonia, PEEP ventilation, porphyria, drugs–eg, chlorpropamide, vincristine, etc Lab Hypervolemia, hypouricemia, ↓ creatinine, hyponatremia, natriuresis–urinary sodium > 20 mEq/L with ↓ BUN, no Sx of volume depletion, ↓ maximum urinary dilution, ↑ ADH, normal renal and adrenal function Management Corticosteroids to suppress ADH secretion