SIADH


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Related to SIADH: diabetes insipidus

syndrome

 [sin´drōm]
a combination of symptoms resulting from a single cause or so commonly occurring together as to constitute a distinct clinical picture. For specific syndromes, see under the name, such as adrenogenital syndrome or reye's syndrome. See also disease and sickness.
syndrome of crocodile tears spontaneous lacrimation occurring parallel with the normal salivation of eating. It follows facial paralysis and seems to be due to straying of the regenerating nerve fibers, some of those destined for the salivary glands going to the lacrimal glands.
syndrome of inappropriate antidiuretic hormone (SIADH) a syndrome in which secretion of vasopressin (antidiuretic hormone) is not inhibited by hypotonicity of extracellular fluid and hyponatremia is produced. It occurs in conjunction with oat cell carcinoma of the lung and certain other malignant tumors and is caused by production of vasopressin by the tumor. See also ectopic hormones.

SIADH

SIADH

syndrome of inappropriate antidiuretic hormone.

SIADH

SIADH

Syndrome of inappropriate antidiuretic hormone secretion. A condition characterised by increased vasopressin/ADH secretion (despite low plasma osmolarity), water retention and dilutional hyponatraemia.
 
Aetiology
Addison’s disease, ACTH deficiency, AIDS, hypopituitarism, paraneoplastic hormone production (small cell carcinoma of lung, bronchogenic, pancreas, uterine, bladder or prostate), lymphoproliferative disorders, mesothelioma, thymoma, CNS disease (trauma, infection, chromophobe adenoma), metastases, lung disease (TB, pneumonia, PEEP ventilation), porphyria, drugs (e.g., chlorpropamide, vincristine, etc.).
 
Lab
Hypervolemia, hypouricaemia, decreased creatinine, hyponatraemia, natriuresis (urinary sodium > 20 mEq/L with decreased BUN), no symptoms of volume depletion, decreased maximum urinary dilution, increased ADH, normal renal and adrenal function.
 
Management
Corticosteroids to suppress ADH secretion.

SIADH

Syndrome of inappropriate antidiuretic hormone secretion, dilutional hyponatremia A complex characterized by ↑ vasopressin–ADH secretion despite low plasma osmolarity, water retention, dilutional hyponatremia Etiology Addison's disease, ACTH deficiency, AIDS, hypopituitarism, ectopic hormone production in CA–small cell, bronchogenic, pancreas, uterine, bladder, prostate, lymphoproliferative disorders, mesothelioma, thymoma, CNS disease–trauma, infection, chromophobe adenoma, metastases, lung disease–TB, pneumonia, PEEP ventilation, porphyria, drugs–eg, chlorpropamide, vincristine, etc Lab Hypervolemia, hypouricemia, ↓ creatinine, hyponatremia, natriuresis–urinary sodium > 20 mEq/L with ↓ BUN, no Sx of volume depletion, ↓ maximum urinary dilution, ↑ ADH, normal renal and adrenal function Management Corticosteroids to suppress ADH secretion

SIADH

Abbreviation for syndrome of inappropriate antidiuretic hormone secretion.

SIADH

Abbrev. for Syndrome of Inappropriate Antidiuretic Hormone. This is a condition in which excessive production of ADH (also known as vasopressin) by the PITUITARY GLAND results in water retention and low levels of sodium. The syndrome occurs in various serious diseases, especially cancer.

SIADH

Abbreviation for syndrome of inappropriate secretion of antidiuretic hormone.

SIADH

syndrome of inappropriate secretion of antidiuretic hormone.
References in periodicals archive ?
Before the appointment, the patient needs to be instructed to report signs and symptoms discussed previously of hypopituitarism, DI, SIADH, CSW, CSF rhinorrhea, infections, and any other illness.
The SIADH paradigm accounts for clinical presentations of EAH that would otherwise be inexplicable such as the delayed onset in runners after races who sometimes continue to force fluids under the mistaken assumption that absence of spontaneous urination must be a symptom of dehydration.
If plasma and urinary ADH results are obtained, they might reveal that the hormone is inappropriately high in patients with SIADH.
Since that initial observation, clinical and experimental data suggest that patients with SAH and other intracranial diseases experience hypovolemia rather than the euvolemia or hypervolemia of SIADH.
Therefore, pending longer, controlled clinical trials, the nicotine patch should be considered as a potential cause of SIADH.
A tendency toward metabolic alkalosis suggests SIADH or diuretic use, whereas metabolic acidosis suggests primary adrenal insufficiency (4).
Another factor that may alert the neuroscience nurse to the potential of vasospasm in a patient is the decreased serum sodium and osmolality with an increased urine sodium and osmolality as seen in SIADH.
Hyponatremia is recognized as an independent contributor to negative patient outcomes in many chronic diseases, most notably CHF, as well as cirrhosis and SIADH.
Gildea JH: High and dry, low and wet: The key to DI and SIADH.
15] There are a variety of causes for SIADH including disorders of the nervous or endocrine systems, pulmonary dysfunction, intake of certain drugs or an idiopathic, ectopic production of ADH.
SALT-1 and SALT-2 [Sodium Assessment With Increasing Levels of Tolvaptan in Hyponatremia] are two multicenter, randomized, double-blind, placebo- controlled studies involving 205 (SALT-1) and 243 (SALT-2) patients with hyponatremia predominantly associated with heart failure, cirrhosis or SIADH.
The regulatory submission of SR 121463, a V2 receptor antagonist that has demonstrated positive phase III results in the treatment of SIADH (syndrome of inappropriate antidiuretic hormone secretion), is planned in 2006.