SHC1

SHC1

A gene on chromosome 1q21 that encodes a widely expressed signalling adapter protein which couples activated growth factor receptors to signalling pathways. SHC1 participates in a signalling cascade initiated by activated KIT and KITLG/SCF. Once phosphorylated, the isoforms p46Shc and p52Shc couple activated receptor tyrosine kinases to Ras by recruiting the GRB2/SOS complex, leading to the cytoplasmic (i.e., non-neuronal) propagation of mitogenic signals; isoform p66Shc regulates the cellular response to oxidative stress and plays a role in stress-activated p53’s ability to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. SHC1 participates in signalling downstream of the angiopoietin receptor TEK/TIE2, and it plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. It is expressed in neural stem cells, but absent in marure neurons.
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In addition, the genetic variant the team discovered in SHC1 is linked to another variant that causes an amino acid change in the protein, possibly changing the function or expression of the protein.
Among the intracellular components in the insulin-signaling pathway, IGF2 expression was the most abundant, followed by AKT1, IGF2R, INSR, IRS1 and IGF1R, but the mRNA levels of INS1, INS2, PIK3CB, and SHC1 were very low in the adipocytes.
4 and Table 2), and SHC1 mRNA levels that were too low to be compared.