SH3 domain


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SH3 domain

Src-homology 3 domain. A small, circa-60-amino acid domain which binds to proline-rich peptides. Proteins with SH3 domain include CDC24, CDC25, crk adaptor protein, cytoplasmic tyrosine kinases—e.g., abl, src, phospholipase, PI3 kinase, Ras GTPase activating protein.
References in periodicals archive ?
SAM and SH3 domain containing protein 1 (SASH1) is identified to be a tumor suppressor gene for breast cancer.
Baker and his colleagues focused on a 57-unit chain, containing 18 different amino, acids, from a protein subunit called the SH3 domain.
The researchers screened the candidate structures for the ability to bind to a peptide that attaches at a specific binding site within the SH3 domain.
Proteins with SH3 domains play a role in cancer, cardiovascular disease, inflammatory disease, diabetes and diseases of the central nervous system.
By year-end, it is anticipated that the database will contain protein pathway information from several other domain families, such as PDZ, SH2 and SH3 domains.
The company expects to make substantial progress toward complete mapping of two additional protein domains -- the PDZ and SH3 domains -- in 2001.