SH3 domain


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SH3 domain

Src-homology 3 domain. A small, circa-60-amino acid domain which binds to proline-rich peptides. Proteins with SH3 domain include CDC24, CDC25, crk adaptor protein, cytoplasmic tyrosine kinases—e.g., abl, src, phospholipase, PI3 kinase, Ras GTPase activating protein.
References in periodicals archive ?
Rubin et al [16] identified two major genes correlated to chicken domestication process through selective-sweep analysis of chicken genome; thyroid stimulating hormone receptor (TSHR) and SH3 domain containing ring finger 2 (SH3RF2) gene.
Identification of the structure of the quail SH3 domain containing ring finger 2 (SH3RF2) gene.
SH3RF2, SH3 domain containing ring finger 2; KO, knockout; QM7, quail myoblast.
1% in SH3 domain and tetratricopeptide repeats 2 gene, 1.
These sequences are separated from the PQVPLR binding site, and would hardly interact with SH3 domain, but instead with a different region of SH3 domain containing protein (45).
The flanking PRR region in p22-phox (amino acids 161-164), adopts an [alfa]-helix (50), and is involved in full activation of the phagocyte oxidase, by fortifying the interaction with the p47-phox SH3 domain.
72-77]) motif is required for interactions with cellular proteins containing SH3 domains, (38), such as tyrosine kinases of the Src family, cytoplasmic tail of CD4, Hck and Vav, and is central to Nef ability to induce cellular activation (30); 7) two arginines at the N-terminus of helix [alpha]4 of Nef ([R.
SAM and SH3 domain containing protein 1 (SASH1) is identified to be a tumor suppressor gene for breast cancer.
Because a GST fusion protein containing an SH2 domain of Fyn can bind to PECAM-1 but an SH3 domain of Fyn cannot, the SH2 domain of cSrc appears to be involved in c-Src binding to tyrosine-phosphorylated PECAM-1.
Baker and his colleagues focused on a 57-unit chain, containing 18 different amino, acids, from a protein subunit called the SH3 domain.
The researchers screened the candidate structures for the ability to bind to a peptide that attaches at a specific binding site within the SH3 domain.