PLAG1

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PLAG1

A gene on chromosome 8q12 that encodes PLAG1, a zinc finger transcription factor that is consistently rearranged in pleomorphic adenomas of the salivary gland. PLAG1 activation results in upregulation of IGFII, leading to uncontrolled cell proliferation in cultured cells; other genes upregulated by PLAG1 include CRLF1, CRABP2, CRIP2 and PIGF.

Molecular pathology
PLAG1 overexpression occurs in pleomorphic adenomas of the salivary gland, lipoblastoma and hepatoblastoma, and co-operates with CBFB-MYH11, a fusion gene in myeloid leukaemia.
References in periodicals archive ?
En la porcion dorsal de la SGPA se observa una estructura semioscura la cual es la Comisura del Coliculo Inferior (CCI) constituida por fibras que comunican entre si a los Coliculos Inferiores.
Designed by architectural firm SGPA, Del Mar Highlands Town Center is located at the SEC of Del Mar Heights Road and El Camino Real and is anchored by Ralph's Fresh Fare, Rite Aid, Ultra Star Cinemas, Barnes & Noble and Jimbo'sO Naturally.
If FGU is unable to execute a replacement GPA within 90 days, then the trustee shall transfer all funds remaining in the SGPA to the Special Redemption Account (SRA).