SGK1

SGK1

A gene on chromosome 6q23 that encodes serum/glucocorticoid-inducible kinase 1, a serine/threonine protein kinase that activates certain K+, Na=, and Cl- channels in response to cell stress, and which appears to be involved in cell survival, neuronal excitability and renal sodium excretion. It is highly expressed in hypertension and diabetic nephropathy.
References in periodicals archive ?
Sixteen significantly mutated genes were discerned in this molecular subgroup (Table 1): 9 genes previously implicated in endometrial cancer (PTEN, PIK3CA, CTNNB1, ARID1A, PIK3R1, KRAS, FGFR2, CHD4, SPOP) by us and others [(17, 18); reviewed in (24)], and 7 genes (BCOR, CSMD3, CTCF, MECOM, METTL14, SGK1, SOX17) not previously recognized to have a role in endometrial tumorigenesis.
Arsenic inhibits SGK1 activation of CFTR Cl-channels in the gill of killifish, Fundulus heterociitus.
They identified a specific gene known as SGK1 that plays an important role in the cells' development.
23andMe also identifieda genetic factor in a gene called SGK1 that may protect against the disease.
Professor Jan Brosens, of Warwick Medical School, believes the enzyme SGK1 is a natural "fertility switch".
High levels of a protein called SGK1 can cause infertility but when there is not enough women are more likely to lose a baby.
The researchers discovered that the womb lining in these women had high levels of the enzyme SGK1.
Later in the year, we also announced the discovery of a potential protective genetic factor against Parkinson's disease in the SGK1 gene.
Among the 9 genes analyzed in human blood samples, the expression of 6 genes, namely, BHLHB2, CCNL1, SE20-4, C8FW, PLK2, and SGK1, was significantly higher in the high-TZCA group than in the low-TZCA group.
Fox Foundation, Will Further Investigate the SGK1 Gene - A First Step Toward Developing Possible Treatments for Parkinson's Disease
In the second 10-min step, the activated SGK1 phosphorylates a synthetic peptide (RPRAATF) using [[gamma]-[.