SETD2

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SETD2

A gene on chromosome 3p21.31 that encodes a ubiquitously expressed histone methyltransferase that specifically methylates Lys-36 of histone H3. Lys-36 methylation is a specific tag for epigenetic transcriptional activation. SETD2 likely plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. It may also act as a promoter-binding transcription activator.
References in periodicals archive ?
Keynote speech presented at the International Conference on Sustainable Development in Building and Environment, SET2 (Sustainable Energy Technology), 24-27 October 2003, Chongqing, China; and appeared also in Journal of Chongqing University (English Edition) 2003; Vol.
The SET2 brings Bluegrass devotees the "Bluegrass Greats" as well as local backyard pickers and singers.