SERPINE1

SERPINE1

A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis.

Molecular pathology
SERPINE1 mutations cause plasminogen activator inhibitor-1 deficiency; high concentrations of the gene product are associated with thrombophilia.
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References in periodicals archive ?
Highly up-regulated genes in colon adenocarcinoma included SERPINE1, previously known as a gene associated with tumor invasion (16,17), and several matrix metalloproteinases, including MMP7 (15).
157399 B (ovalbumin), member 5 SERPINE1 Serpin peptidase inhibitor, clade 1.
86 Model features Pathways Gene SERPINE1 (PAI-1); MMP9 GO: Process Regulation of angiogenesis; fibrinolysis; blood coagulation; positive regulation of apoptosis KEGG p53 signaling pathway; complement coagulation cascades IPA Coagulation system; acute phase response signaling GO: Function Serine type endopeptidase activity; transmembrane receptor activity; collagen binding GO: Extracellular region; integral to membrane Component ToxCast BSK:BE3C (bronchial epithelial cells): PAI-1 down assays Abbreviations: AUC, area under receiver operating characteristic curve; BA, balanced accuracy; CV, cross validation; MMP9, matrix metalloproteinase 9.