The USPSTF review of seven large randomized controlled trials evaluating women without preexisting breast cancer showed that SERMs
can be utilized to decrease the incidence of invasive breast cancer in postmenopausal women by 30%-55%, or 7-9 fewer events per 1,000 in a 5-year period.
To measure non-adherence to therapy, we identified the subset of sample members who had at least one PDE record for SERM
or AI and who had at least 12 consecutive months of Part D enrollment following the first filled prescription for either drug.
Effects of ospemifene, a novel SERM
, on biochemical markers of bone turnover in healthy postmenopausal women.
Two other SERMs
have been developed--lasofoxifene and arzoxifene.
appear to be a good substitute for progestin.
While it is true that Osphena has not been studied in such women, the class effect of all SERMs
in addition to the basic science data speak for themselves.
For example, drugs used to treat hypertension and lower cholesterol, both markers of coronary artery disease, have more adverse effects--and more serious ones--than SERMs
Like other SERMs
, lasofoxifene raises the risk of venous thromboembolism and increases the rate of hot flushes and leg cramps, wrote Dr.
Arzoxifene is a benzothiophene-class SERM
, like raloxifene, which is approved in postmenopausal women for the treatment and prevention of osteoporosis as well as for invasive breast cancer risk reduction in such women who are at high risk for the cancer or who have osteoporosis.
He reported being an investigator in a study of a SERM
manufactured by Wyeth Pharmaceuticals.
As expected, the SERM
had no effect on the rate of estrogen receptor-negative breast cancers.
Lise Warming, a researcher who studied the SERM
for the Center for Clinical and Basic Research in Ballerup, Denmark, called the levormeloxifene story "disturbing.