Two other SERMs
have been developed--lasofoxifene and arzoxifene.
appear to be a good substitute for progestin.
HCI: A novel raloxifene analogue with improved SERM
potency and efficacy in vivo.
TABLE 28 GLOBAL SERM
MARKET REVENUES, THROUGH 2014 ($ MILLIONS)
So the challenge today is how to communicate to the public to enhance the utilization of SERMs
and reduce further the incidence of breast cancer.
Like other SERMs
, lasofoxifene raises the risk of venous thromboembolism and increases the rate of hot flushes and leg cramps, wrote Dr.
The chief risk associated with the SERM
was a twofold increase in venous thromboembolic events (from 0.
According to the article, "Panelists and audience members noted that vaginal prolapse was seen in animal studies and uterine prolapse in human studies of raloxifene, another SERM
Table 11: Global SERM
Market by Region for the Period
Some women may alternatively benefit from the use of an estrogen-like medicine such as the selective estrogen-receptor modulator (SERM
) raloxifene, although SERMs
too can occasionally lead to hot flashes.
Lise Warming, a researcher who studied the SERM
for the Center for Clinical and Basic Research in Ballerup, Denmark, called the levormeloxifene story "disturbing.
If Phase III clinical trial data confirms this, we forecast that arzoxifene will become the market-leading SERM
, generating sales of $600 million in 2018.