Bio-Rad's sales force could provide a new market push for SELDI
, however, the company may be betting on the eventual development of diagnostic applications to drive technology sales.
An advantage of the SELDI
technique is that target proteins can be characterized after they have been retained and purified on an affinity surface uniquely designed according to the specific properties of the proteins (37).
The patent also covers the measurement of these new modifications of BNP by a variety of methods, including SELDI
(surface enhanced laser desorption/ionization) mass spectrometry -- which was used to discover these specific forms -- and other immunoassay approaches.
Among other projects, Merrick's group uses SELDI
to examine the mechanisms of action of two key proteins involved in cell growth and cell death--p53 and NFKB.
The method, invented at Ciphergen, called "Differential Retentate Chromatography," is an advanced form of SELDI
(surface enhanced laser desorption/ionization) time-of-flight mass spectrometry.
was developed by the Fremont, CA-based company, Ciphergen, who make and distribute the instruments used for this research.
The genesis of what has been referred to as the "SELDI
fiasco" (3) traces back to the early success and attendant hyperbole associated with the apparent differentiation of ovarian cancer patients from their unaffected controls by a pattern of uncharacterized peaks presented in the low-mass region of native serum SELDI
mass spectrometry, the TTP test directly measures enzymatic levels and is expected to provide precise, quantitative and reproducible results with better turnaround time when compared to current methods.
is being investigated for potential use in serum biomarker development and classification of control and toxicant-exposed experimental animals.
Pall and Ciphergen also announced an alliance to develop and promote Ciphergen's patented SELDI
ProteinChip(R) technology as a bridge between the research lab and large scale drug production.
None of our individual biomarker candidates [the final 7 SELDI
marker candidates were ITIH4 (inter-[alpha]-trypsin inhibitor heavy chain 4), transthyretin, apolipoprotein A1, hepcidin, [[beta].
We believe this patent further validates the innovation underlying SELDI
technology and look forward to receiving Bio-Rad's payment," said Gail S.