MAP2K4

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MAP2K4

A gene on chromosome 17q11.2 that encodes a MAPK kinase belonging to a protein kinase signal transduction cascade. MAP2K4 is a dual-specificity kinase and an essential component of the MAP kinase signal transduction pathway. It is also an essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signalling pathway, which is involved in the mitochondrial death signalling pathway, including the release cytochrome c, leading to apoptosis. With MAP2K7/MKK7, it is the only known kinase to directly activate the SAP/JNKs MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3; whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 also activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. It is widely expressed in tissues, especially in skeletal muscle.
References in periodicals archive ?
NORDIC BUSINESS REPORT-November 6, 2017-SAS reports preliminary income of SEK1.
M2 EQUITYBITES-November 6, 2017-SAS reports preliminary income of SEK1.
Swedish Orphan Biovitrum AB (Sobi) (STO:SOBI), an international speciality healthcare company dedicated to rare diseases, on Wednesday reported profit of SEK324m, or EPS of SEK1.
TELECOMWORLDWIRE-21 April 2010-Swedish Tele2 net profit surges to SEK1.
Scandinavian airline group SAS Group reported on Wednesday a net loss of SEK1,795m, or SEK1.
This was a decrease of 21% in comparison with profit of SEK310m, or EPS of SEK1.
TELECOMWORLDWIRE-1 February 2007-TeliaSonera AB acquires Danish service provider Debitel Danmark A/S in SEK1.
M2 EQUITYBITES-October 24, 2017-Wihlborgs Fastigheter posts record profit of SEK1,495m in Q3 2017
NORDIC BUSINESS REPORT-October 24, 2017-Wihlborgs Fastigheter posts record profit of SEK1,495m in Q3 2017
M2 PHARMA-November 2, 2011-Meda's Q3 EBITDA improves to SEK1.
Revenues for the quarter were up by 1% to SEK1,584m, as compared with SEK1,573m in Q2 2016.
1 November 2011 - Swedish medical technology firm Glycorex Transplantation AB (NGM:GTAB B) recorded on Tuesday a third-quarter net profit of SEK1.