MAP2K4

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MAP2K4

A gene on chromosome 17q11.2 that encodes a MAPK kinase belonging to a protein kinase signal transduction cascade. MAP2K4 is a dual-specificity kinase and an essential component of the MAP kinase signal transduction pathway. It is also an essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signalling pathway, which is involved in the mitochondrial death signalling pathway, including the release cytochrome c, leading to apoptosis. With MAP2K7/MKK7, it is the only known kinase to directly activate the SAP/JNKs MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3; whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 also activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. It is widely expressed in tissues, especially in skeletal muscle.
References in periodicals archive ?
Swedish broadband operator Sky Communication in Sweden AB (SkyCom) said on Wednesday (19 October) that it had entered into an agreement to acquire the Internet services provider Orexis Communication AB for SEK1.
3 November 2009 - Scandinavian air travel group SAS AB (STO: SAS) and privately-held company Salenia AB have agreed to sell their jointly owned venture Skyways Express AB to its CEO Lars-Ake Bertilsson for SEK1.
The first stage of the order has been valued at around SEK1.
Scandinavian airline group SAS Group reported on Wednesday a net loss of SEK1,795m, or SEK1.
The boards of the companies have decided to propose to their respective shareholders that the companies merge to form the world's third largest Internet consultancy called Cell Network AB with aggregate revenues of SEK1.
Operating profit for the nine-month period decreased from SEK1,095m, while revenue increased from SEK45,738m, as compared to the corresponding period in 2007.
Net profit at the Swedish bank has declined to SEK1.
Scandinavian airline operator SAS Group (OMX Stockholm: SAS) (OMX Copenhagen: SAS DKK) reported on Thursday (14 August) an operating loss of SEK1,226m on revenue of SEK32,532m for the period January-June 2008.
The total value of the agreement is SEK1,750m, SAS said.
General Motors Corporation (GM) (NYSE: GM), the world's largest automaker, has allocated SEK1.
SAS said that the details of the agreement are confidential but the company confirms the total financial compensation is slightly more than SEK1.
Operating loss for the three-month period improved from the loss of SEK1,134m in the corresponding period in 2006, while revenue increased from SEK12,976m.