CXCR4

(redirected from SDF-1 receptor)

CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.
References in periodicals archive ?
cells that express the SDF-1 receptor CXCR4 (C-X-C chemokine receptor type 4) could be tracked in portal vein blood and that this cell subpopulation drove metastasis exclusively.
To determine the role of SDF-1 in mediating the effects of LMWF, a specific inhibitor of the SDF-1 receptor CXCR4, AMD 3100 (20 microg/kg/day), was used.
Study has indicated that over-expression of SDF-1 can promote the stem and progenitor cell migration to the heart, while administration of free neutralizing SDF-1 antibodies or a SDF-1 receptor blocker diminishes the recruitment of BM-derived cells after MI (Broxmeyer et al.
CTCE-0214 is a stable peptide analog of stromal cell-derived factor-1 (SDF-1) and an agonist of the SDF-1 receptor called CXCR4, a key signaling protein in the proliferation, homing, engraftment and expansion of hematopoietic stem cells and white blood cells.