CXCL12

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CXCL12

A gene on chromosome 10q11.1 that encodes a stromal cell-derived alpha chemokine of the intercrine family which, once bound to its receptor, CXCR4, activates lymphocytes, an interaction that has been implicated in the metastasis of breast and other cancers.

Molecular pathology
CXCL12 mutations are associated with resistance to HIV-1 infections.
References in periodicals archive ?
He explained that unlike other tissues, the heart muscle does not release sufficient SDF-1 to attract the number of stem cells to promote complete self-healing, often resulting in scar tissue formation and an impairment of normal heart function.
The chemokine SDF-1 is a chemo-attractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.
SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes.
In the mouse, SDF-1 appears to be required for the execution of the last step when the cells colonize the genital ridge which expresses the chemokine," says Erez Raz of the Max Planck Institute for Biophysical Chemistry in Gottingen, Germany, who led the Cell study.
Although it would be difficult, if not impossible, to confirm that SDF-1 guides the migration of primordial germ cells in a human embryo, Nagasawa says that his group will study whether human 2 primordial germ cells make the chemokine's receptor.
The patents Bioheart has acquired covering the myogenic cells and SDF-1 compositions and methods are expected to provide intellectual property protection until 2023.
MyoCell and MyoCell SDF-1 are trademarks of Bioheart, Inc.
We studied SDF-1 gene polymorphisms in polycythemia vera (PV) and essential thrombocythemia (ET) to determine the frequency of the SDF1-3'A polymorphism and to evaluate its impact on susceptibility to these diseases and on the occurrence of thrombotic complications.
Odds ratios (ORs) were calculated as an index of the association of the SDF-1 genotypes (GG, AG, AA) with each disease.
SDF-1 is a cytokine, a small protein that enables cells to "talk" to one another.
In RegenMed's animal model of proliferative retinopathy (growing vessels into the eye), SDF-1 is expressed in response to injury, and cells are called in to repair the damaged blood vessels.
SDF-1 is a protein with multiple perceived benefits, including angiogenesis (formation of new blood vessels which can provide nutrients to newly engrafted cells) and stem cell homing (attraction of other stem cells to transplantation site for the purpose of helping with the healing process).