CCL3

(redirected from SCYA3)

CCL3

A gene on chromosome 17q12 that encodes a small inducible cytokine, commonly known as macrophage inflammatory protein 1 (MIP-1) alpha, which is produced by CD8+ T cells and is a major HIV-suppressive factor. It binds to chemokine receptors CCR1, CCR4 and CCR5.
References in periodicals archive ?
Compared to Caucasian tumours, African American tumours were almost two times more likely to have loss of the CDKN2A (cyclin-dependent kinase inhibitor 2A) gene and gain of the SCYA3 (small inducible cytokine A3) gene.
CDKN2A is important to cell cycle regulation, and the SCYA3 gene product has dual roles of tumour lymph node metastasis and local host defence against tumours in HNSCC.
The genes most predictive of overall survival in DLBCL were LMO2, BCL6, FN1, CCND2, SCYA3 and BCL2.