SCN9A

SCN9A

A gene on chromosome 2q24 that encodes an alpha subunit of the voltage-gated sodium channel, which mediates voltage-dependent sodium ion permeability of excitable membranes. The SCN9A protein product plays a major role in nociception signalling.

Molecular pathology
SCN9A mutations are associated with primary erythromelalgia, channelopathy-associated insensitivity to pain and paroxysmal extreme pain disorder.
References in periodicals archive ?
Another kind of venom--this time from a Chilean tarantula--could hold the key to alleviating pain associated with chronic conditions and an extremely rare illness called inherited erythromelalgia, which is associated with the SCN9A gene.
A Role of SCN9A in Human Epilepsies, As a Cause of Febrile Seizures and As a Potential Modifier of DravetSyndrome.
An SCN9A Channelopathy Causes Congenital Inability to Experience Pain," Nature 444 (December 14, 2006): 894-98.
Ahora se conoce que este padecimiento es causado por mutaciones en el gene SCN9A, que desactiva el canal Nav 1.
A few genetic studies have provided evidence that SCN9A genetic mutations affecting the sodium channel [Na (v) 1.
Scientists already knew that mutations in another gene, SCN9A, can cause congenital insensitivity to pain (SN: 6/30/12, p.
For limiting the the SCN9A sodium channel, the novel chemical entity XEN402 is formulated.
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes.
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders.
A Sodium Channel Gene SCN9A Polymorphism that Increases Nociceptor Excitability.
The researchers found the protein made by the mutated version of the gene known as SCN9A stays open longer than the normal one.