SCN9A

SCN9A

A gene on chromosome 2q24 that encodes an alpha subunit of the voltage-gated sodium channel, which mediates voltage-dependent sodium ion permeability of excitable membranes. The SCN9A protein product plays a major role in nociception signalling.

Molecular pathology
SCN9A mutations are associated with primary erythromelalgia, channelopathy-associated insensitivity to pain and paroxysmal extreme pain disorder.
References in periodicals archive ?
Scientists already knew that mutations in another gene, SCN9A, can cause congenital insensitivity to pain (SN: 6/30/12, p.
The protein seems to be present only in pain cells and their precursors, as opposed to the protein made by SCN9A, which is found in the pancreas and some other locations.
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes.
For limiting the the SCN9A sodium channel, the novel chemical entity XEN402 is formulated.
Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders.
The researchers found the protein made by the mutated version of the gene known as SCN9A stays open longer than the normal one.
7 is a uniquely interesting target in the multi-billion dollar market for pain therapies based on the inability of families from Northern Pakistan who hold mutations in the SCN9A gene (which encodes the Nav1.
Besides their inability to feel pain, the Pakistani individuals studied by the scientists had something else in common: mutations in a gene called SCN9A.
We also recently reported strong progress in our pain programs, including our sodium channel program targeting SCN9A, a promising molecular target for neuropathic pain recently highlighted by a group of independent investigators.
7 in most mammals and SCN9A in humans--than most other mammals, except for caved-welling microbats, which also live in chemically challenging environments.
NASDAQ: ICGN) today provided an update on its research programs focused on sodium channels including the sodium channel target SCN9A for the treatment of chronic pain.
The team eventually zeroed in on mutations in SCN9A, a gene that encodes part of a cell-surface channel that lets sodium into pain-sensing nerve cells as part of signal propagation.