SCN1B

SCN1B

A gene on chromosome 19q13.1 that encodes a beta subunit of a transmembrane glycoprotein complex, which forms a voltage-gated sodium channel. The beta-1 subunit modulates the kinetics of channel inactivation.

Molecular pathology
SCN1B mutations are linked to generalised epilepsy with febrile seizures, Brugada syndrome 5 and defects in cardiac conduction.
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Primary Insecticide class Mode of Vulnerable neurological action genetic target subpopulations AChE OP Inhibition PON1 polymorphisms CB Inhibition Voltage-gated OC Modified SCN1A, SCN1B sodium gating channel kinetics pyrethrin/pyrethriod Modified HCE1 (CES1) gating kinetics GABA-gated Cyclodienes (a form Antagonism HCE2 (CES2) GABA chloride of OC) receptor channel polymorphisms Phenylpyrazole Antagonism nAChR(a) Neonicotinoid Agonism Haploinsufficiency of [alpha]7 nAChR Adapted from Scharf (2003).
Johnson has authored and co-authored numerous publications on the nature, identity and function of several epilepsy and neurovascular related genes including FEB2, a febrile seizure susceptibility gene, SCN1B, a Febrile seizure "plus" gene, and CCM1, CCM2 and CCM3, three causative genes for cerebral cavernous malformations.