SCN10A

SCN10A

A gene on chromosome 3p22.2 that encodes a voltage-gated sodium ion channel, which is an integral membrane glycoprotein. It is responsible for the initial rising phase of the action potential in most excitable cells.
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Dan Hu presented a poster introducing SCN10A as a new susceptibility gene for Brugada syndrome.
Its neighbor, SCN10A, previously was an unsuspected player in cardiac electrical activity.
To further investigate one of the 22 regions deemed significant, team members used mouse hearts to find where in the heart the ion channel protein products of the SCN10A gene form, locating an abundance of them in the fibers that conduct electrical signals.
Intriguingly, SNPs on chromosome 3 linked to both longer PR interval and QRS duration are in the gene encoding SCN10A, a sodium channel that has never before been linked to heart activity.
The researchers claimed that the damage or mutations to the gene - known as SCN10A - increase the risk of heart disease.
They found that variation in the gene SCN10A was linked with slow and irregular heart rhythms, including risk of ventricular fibrillation.