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SCID mouse

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SCID mouse,
(severe combined immunodeficiency) a strain of mice lacking in T and B lymphocytes and immunoglobulins, either from inbreeding with an autosomal-recessive trait or from genetic engineering, used as a model for studies of the immune system.

mouse [mows]
a small rodent, various species of which are used in laboratory experiments.
1. a small loose body.
2. a computer pointing device.
joint mouse a movable fragment of synovial membrane, cartilage, or other body within a joint; usually associated with degenerative osteoarthritis and osteochondritis dissecans.
knockout mouse a mouse that has had a specific gene artificially deleted from its genome.
nude mouse a mouse homozygous for the nu gene; these mice are hairless, lack a thymus, and thus lack T lymphocytes.
peritoneal mouse a free body in the peritoneal cavity, probably a small detached mass or omentum, sometimes visible radiographically.
SCID mouse (severe combined immunodeficiency) a strain of mice lacking in T and B lymphocytes and immunoglobulins, either from inbreeding with an autosomal recessive trait or from genetic engineering, used as a model for studies of the immune system.


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In a SCID mouse model, lodenosine demonstrated potent antiviral activity against HIV and was superior to AZT.
Mosier says his results indicate that a single injection of the human immune cells reconstitutes the ability to respond to antigens for the life of the SCID mouse receiving the transplant.
 
 
 
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