SC disease

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SC disease

Sickle-hemoglobin C disease A hemoglobinopathy affecting circa 1:800 US blacks, characterized by ↑ infections–eg, bacterial meningitis, Salmonella osteomyelitis due to a defect in the alternate–properdin complement pathway; other effects of SC disease include osteoporosis–resulting in formation of 'fishmouth vertebrae', nephropathy with ↓ renal concentration, acidification, ↑ glomerular filtration rate, retinopathy–in ± 75% of SCD vs 15% of Pts with sickle cell anemia Fundoscopy 'Black sunburst' pattern, due to ↑ glycolysis in end-arterioles; 'seafoam' pattern of proliferative retinopathy Lab ↑ 2,3 DPG, ↑ factor VIII; ↓ osmotic fragility; reticulocytes comprise 5-25% of peripheral RBCs, which have a 'holly-leaf' or navicular shape. See Sickle cell anemia.

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Black Sunburst Pattern disease hemoglobin C disease hemoglobin SC disease Hemoglobinopathies hemoglobinopathy hydroxyurea Nutcracker Phenomenon sickle cell disease sickle cell thalassemia sickle cell-hemoglobin C disease sunburst pattern			Case Report A 36-year-old black male with a history of hemoglobin SC disease presented with severe left hip pain. Acute splenic sequestration crisis resembling sepsis in an adult with ... by Brotman, Daniel J. / Southern Medical Journal This rare neoplasm has been associated with sickle cell trait in all reported cases but one in which the patient had hemoglobin SC disease. Gross hematuria in a 20-year-old black woman with sickle cell trait. ... by Hoenig, Jeanette D.; Husain, Aliya N.; Waters, Bedford W. / Archives of Pathology & Laboratory Medicine			Savlon Savory Food Snack SAVS Savvy saw saw palmetto sawdust sawdust liver Sawfish Pattern sawfly sawhorse stance Sawtooth Pattern saxitoxin Saxon Saxony Sayre elevator Sayre's jacket Sb SBE SBLA syndrome SBO SBP SBS side-bending/rotation SBT Sc SC disease Sc.D SCA scab scabbard trachea scabby scabby cat disease scabby mouth scabicide scabies scabietic Scabiosa succisa scabious scabrities unguium scad scaffold Scaffold Protein scag scala scala tympani scala vestibuli scalar scald scalded skin syndrome scalding scale			SBYA SBYB SBYC SBYD sBYDV SBYF SBYFL SBYO SBYP SBYPC SBYRA SBYRC SBYS SBYSC SBYSP SBYV SBZ SC SC SC SC SC SC SC (AD) SC (HCD) SC asphalt SC Bose SC Card SC connector SC disease SC IHDC SC MC Sc spiral galaxy SC star SC TIF SC&A SC&CU SC&D SC&M SC&OS SC&RA SC&RO SC(PS) SC+AL SC-21 SC-2D SC-CDMA SC-CP SC-CPM SC-CSRS SC-D SC-DRG SC-EL SC-FDE

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