shares similar characteristics with MERS-CoV, including likely zoonotic origin and transmission (17-20).
The most recently publicized human coronavirus, SARS-CoV
which causes SARS, has a unique pathogenesis because it causes both upper and lower respiratory tract infections and can also cause gastroenteritis.
His team was the first group in the world to identify the peptidic fusion inhibitors of SARS-CoV
and MERS-CoV, and to demonstrate that the receptor-binding domain (RBD) of coronavirus is an important target for developing SARS and MERS vaccines.
became the originator of this infection.
They identified four compounds that inhibited MERS-CoV, SARS-CoV
and Human Coronavirus 229E at relatively low concentrations.
pandemic killed 774 people of the 8094 people infected, a case fatality ratio of almost 10 per cent.
, which sparked a global health scare in 2003 and killed 800 people, had a 10 per cent death rate, while the fatality rate is as high 50 per cent with Mers-Cov, causing grave concerns among health officials.
was isolated from sputum samples, nasal secretions, bronchial washings, serum samples, and fecal samples (8).
As a precaution against contracting highly communicable diseases--such as SARS-CoV
(Severe Acute Respiratory Syndrome coronavirus), influenza, and even the common cold--some people carry hand-sanitizing solutions and disposable antiseptic wipe cloths for use in high-risk public places.
All but one of the suspected or confirmed cases are believed to stem from contact with a female laboratory worker, a postgraduate student who worked at the Chinese National Institute of Virology in Beijing, where researchers were studying SARS-CoV
The lead compound within Maxim's MX128533 series has demonstrated inhibition of the SARS-CoV
in cell culture at very low concentrations (0.
is a novel virus within the coronavirus family.