MAPK9

(redirected from SAPK)
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MAPK9

A gene on chromosome 5q35 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK9 is activated by various cell stimuli and targets specific transcription factors, mediating immediate early gene expression in response to cell stimuli. MAPK9 is closely related to MAPK8, and both are involved in UV light-induced apoptosis; MAPK9 blocks the ubiquitination of tumour suppressor p53, increasing p53 stability in non-stressed cells, and plays a key role in T cell differentiation.
References in periodicals archive ?
Abbreviations: Caspase, cysteine-dependent aspartate-directed protease; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; SAPK, stress-activated protein kinase; VP16, etoposide.
Abbreviations: NF-[kappa]B, nuclear factor-kappaB; mapk, mitogen-activated protein kinase; P13K, phosphatidylinositide 3-kinase: Akt, protein kinase B; FAK, focal adhesion kinase; PSG, prostate-specific G-protein-coupled receptor; IL-6, interleukin-6; JNK, c-Jun NH(2)-terminal kinase; TLC, thin layer chromatography; NMR, nuclear magnetic resonance; FBS, fetal bovine serum; DCC, dextran coated charcoal slurry; RT, room temperature; GC-MS, gas chromatography-mass spectrometry; MIC, minimum inhibitory concentration; AIDS, acquired immunodeficiency syndrome; PI, propidium iodide; RI, retention indices; AP-1, activator protein 1; CREB, cAMP response element-binding protein; c/EBP, CCAAT/enhancer binding protein; SAPK, stress-activated protein kinases.
Three subfamilies of MAPKs have been identified: ERK, p38, and JNK, which is also known as stress-activated protein kinase or SAPK.