DLGAP3

(redirected from SAPAP3)

DLGAP3

A gene on chromosome 1p35.3-p34.1 that encodes disks-associated protein 3, a membrane-associated guanylate kinase that may play a role in the molecular organisation of synapses and neuronal cell signalling, and which may act as an adapter protein linking ion channels to the subsynaptic cytoskeleton.
References in periodicals archive ?
The targeted gene makes a protein known as SAPAP3, which fosters brain-cell communication via the chemical messenger glutamate, especially in the striatum, a structure near the top of the brain stem.
Further study of the gene for SAPAP3 and related genes in mice and people may lead to new drug treatments for OCD, Feng's team reports in the Aug.
Video surveillance confirmed that mice without the gene for SAPAP3 slept fitfully and caused their own skin injuries by excessively grooming themselves.
Feng's analyses of neural tissue from mutant mice indicate that the lack of SAPAP3 suppresses activity in the striatum usually triggered by glutamate, and that this cutback stunts connections between the striatum and the cortex.
When the scientists injected the striata of 7-day-old mutant mice with a substance containing the gene for SAPAP3, the animals didn't develop grooming abnormalities or anxiety.