DLG3

(redirected from SAP102)

DLG3

A gene on chromosome Xq13.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family thought to play a role in clustering of NMDA receptors at excitatory synapses; it may also downregulate cell proliferation by interacting with the C-terminal region of the adenomatosis polyposis coli tumour suppressor protein. DLG3 is also the retired HUGO symbol for what is now designated MPP3, see there. 

Molecular pathology
DLG3 mutations are associated with X-linked mental retardation.
References in periodicals archive ?
For instance, during early postnatal development, immature hippocampal synapses contain SAP102 and NMDARs with GluN2B (Fig.
As SAP102 is replaced by PSD95, G1uN2B is replaced by G1uN2A (Sans et al.
Multiple MAGUKs, including SAP102 and PSD95, interact with GluN2A and GluN2B at this site (Rutter and Stephenson, 2000), suggesting that other direct or indirect subunit-specific interactions exist to confer greater precision placement of GluN2A at synaptic active zones (Cousins et al.
For instance, fusing the amino and TM regions of GluN2A to the carboxy terminus of GluN2B should produce an NMDAR that conducts as if it contained GluN2A, but can be inserted into juvenile synapses that contain SAP102 (Fig.
An ABc mutant NMDAR would be expected to mimic overexpression of GluN2A at immature synapses, due to the non-specificity of the predominating PSD anchoring protein, SAP102, for GluN2A or G1uN2B.
Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder.