Also found in: Acronyms.


Abbreviation for S-adenosyl-l-methionine.




A compound that is synthesized naturally in the central nervous system when folate and vitamin B12 levels are adequate. It is involved in the methylation of neurotransmitters, amino acids, proteins, phospholipids, and other neurochemicals. The chemical is used as a treatment for depression, liver disease, and osteoarthritis. It is an active sulfonium form of methionine that acts as a methyl group donor in various reactions (such as the formation of epinephrine or creatine).


References in periodicals archive ?
Improved stability utilizing the salts of SAM-e "is also directly correlated with the size and shape of the product itself in drying phase.
14) In this manner it may serve to complement the actions of SAM-e.
30) TMG plays a role in supporting the process of methyl donation either directly via the methylation of homocysteine, or indirectly by supporting the body's production of SAM-e.
In eight other studies, SAM-e produced the same "modest" pain relief as NSAIDs like aspirin and ibuprofen.
To make SAM-e seem less costly, manufacturers typically recommend taking less, though there's little evidence that less works.
About half of the brands tested during the past few years contained less SAM-e than their labels claimed.
These new findings suggest that SAM-e works as effectively as prescription drugs and it does it without the side effects," added Dr.
The Evidence Report summary concludes that SAM-e appears to work as effectively as non-steroidal anti-inflammatory drugs (NSAIDS) in treating osteoarthritis.
SAM-e (pronounced "sammy") is the user-friendly name for S-adenosylmethionine, a biochemical workhorse that's found in every cell of our bodies.
Healthy, well-nourished people seem to make all the SAM-e they need from the amino acid methionine, which is found in protein.
For patients like 48-year-old Debbie Bonick, who has suffered from depression for more than 15 years, the combination therapy of SAM-e and prescription antidepressants under physician supervision has proven a success.
Then, Bonick read about SAM-e and talked to her doctor about it.