SALL4

SALL4

A gene on chromosome 20q13.2 that encodes a zinc finger transcription factor, which may be involved in musculoskeletal embryogenesis.

Molecular pathology
SALL4 mutations cause Duane-radial ray syndrome.
References in periodicals archive ?
SALL4 is a novel diagnostic marker for testicular germ cell tumors.
SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors.
Diagnostic utility of SALL4 in extragonadal yolk sac tumors: an immunohisto-chemical study of 59 cases with comparison to placental-like alkaline phosphatase, alpha-fetoprotein, and glypican-3.
Brigham and Women's, Boston Chai will target SALL4 in the treatment of acute myeloid leukemia (AML).
39) Immunophenotypically, sex cord-stromal tumors are often positive for inhibin, Melan-A, and calretinin and are uniformly negative for fetal germ cell and other markers that stain seminoma, including OCT3/4, SALL4, PLAP, CD117, and D2-40.
As a general marker for TGCT, SALL4 is frequently expressed in teratoma, (41) but its expression in dermoid and epidermoid cysts is, to our knowledge, unknown.
103,104) Most recently, SALL4 has been shown to demonstrate strong nuclear staining in germinoma, embryonal carcinoma, and yolk sac tumors.
SALL4 is a novel diagnostic marker for testicular germ cell tumors [published online ahead of print April 22, 2009].