BRSK1

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BRSK1

A gene on chromosome 19q13.4 that encodes a serine/threonine kinase required for the polarisation of forebrain neurons, which endows axons and dendrites with distinct properties, possibly by regulating phosphorylation of microtubule-associated proteins at specific regions. BRSK1 is thought to help regulate G2/M arrest in response to UV light-induced DNA damage; it phosphorylates WEE1, CDC25B and CDC25C. It is widely expressed, especially in the brain and testes; it localises to synaptic vesicles in neurons.
References in periodicals archive ?
Stobart said that the distribution centre asset was held in SAD1 Stobart Air Development 1 Ltd.
76-kb DNA fragment containing only the 5' regulatory region and a part of the untranslated region of the SAD1 gene was amplified by PCR and cloned into the pCRII vector (Invitrogen Corp.
2 kb of the promoter regions of the SAD1 and SAD2 gene, respectively (Fig.
In the SAD2 gene promoter, 368 bp corresponding to nucleotides 759 to 391 in the SAD1 gene promoter were also absent.
In contrast, the SAD1 promoter was weaker, and little or no activity was detected in tissues other than roots and seeds.
In contrast, the SAD1 promoter was considerably weaker and appeared to be root- and seed-specific.