MBTPS1

(redirected from S1p)
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MBTPS1

A gene on chromosome 16q24 that encodes a sterol-regulated subtilisin-like serine protease, which cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), releasing transcriptionally active SREBP fragments for translocation to the nucleus.
References in periodicals archive ?
While testing a chemical inhibitor of S1P activity, Espenshade says, he and his team added the chemical to hamster cells and were surprised to find that SCAP disappeared from the cells.
It readily crosses the BBB and interacts with central S1P receptors.
Toxicological investigation of the substance, S1P, and the nano-particle cream
In addition, bioactive lipid components such as S1P are preferentially associated with the HDL3c particle subset.
Lpath's lead product candidate, Sphingomab, targets the bioactive lipid, S1P.
Now, Tilly's group has started to investigate whether S1P might protect not just mice but women undergoing radiation therapy.
has acquired S1P patents, know-how and global commercialisation rights from the
ONO-4641 (S1P receptor agonist) Data blitz (1) presentation followed by a poster presentation - A double-blind, placebo-controlled, Phase II, 26-week DreaMS trial of a selective S1P receptor agonist ONO-4641 in patients with Relapsing-Remitting Multiple Sclerosis (presentation #013, Wednesday, April 25, 2012, 6:21 PM)
Hermann Ziltener and his research team at UBC's Biomedical Research Centre have identified a molecule called S1P that can tell the thymus to 'open the gates' and accept more stem cells.
S1P is a circulating lipid that binds to five GPCRs termed S1P1-5.
8) This robust clinical trial programme strengthens the potential for fingolimod to be the first approved product in a new therapeutic class called S1P receptor modulators.
Antibodies against the S1P receptor, created from the patient's antibody-producing cells, were injected into mice that were induced to develop colitis.