S1PR1

S1PR1

A gene on chromosome 1p21 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor, which is highly expressed in endothelial cells. It binds the sphingosine-1-phosphate with high affinity and high specificity, and may be involved in regulating endothelial cell differentiation. Receptor activation induces cell–cell adhesion.
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ANGPT1, TIE2, PDGFR-B, CDH5, S1PR1, FGF2, Shh, and TGFRB1), and blood vessel maturation/formation factor (e.
S1PR1 is one of five G protein-coupled receptors (S1PR1-5) of sphingosine-1-phosphate (S1P) (Hannun and Obeid, 2008), which is a potent lipid mediator produced from the metabolism of sphingolipid by the actions of sphingosine kinase.
TABLE 49 DRIVERS AND RESTRAINTS OF S1PR1 INHIBITORS AS A NEW CLASS OF DRUGS FOR IMMUNE DISEASES 78