S1PR1

S1PR1

A gene on chromosome 1p21 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor, which is highly expressed in endothelial cells. It binds the sphingosine-1-phosphate with high affinity and high specificity, and may be involved in regulating endothelial cell differentiation. Receptor activation induces cell–cell adhesion.
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Selective binding with S1PR1 is thought to suppress a specific sub set of activated lymphocytes from migrating to sites of inflammation, which is likely to decrease circulating T and B lymphocytes that result in anti-inflammatory activity.
The failure of these cells to exit the tissue is currently thought to be due to their low expression of the transcription factor KLF2 and of S1PR1 and to their high expression of the C-type lectin CD69; as a result of these conditions, the cells fail to respond to an "exit cue" provided by S1P (sphingosine-1-phosphate), which is released mainly from lymphatic ECs.
Global Markets Direct's, 'Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1) - Pipeline Review, H1 2016', provides in depth analysis on Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1) targeted pipeline therapeutics.
The report provides comprehensive information on the Sphingosine 1-Phosphate Receptor 1 (S1P Receptor 1 or Endothelial Differentiation G-Protein Coupled Receptor 1 or Sphingosine 1-Phosphate Receptor Edg-1 or CD363 or S1PR1 or CHEDG1 or EDG1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
ANGPT1, TIE2, PDGFR-B, CDH5, S1PR1, FGF2, Shh, and TGFRB1), and blood vessel maturation/formation factor (e.
The underlying mechanism is likely that CF whole extract up-regulated expression of certain genes for angiogenesis and associated growth factors and receptors, including IGF1, CTGF, NRP2, VEGFR3, HIF1A, MMP2, MMP9, TIMP2, PLG, PLAU, ITGAV, 1TGB3, beta-catenin, PECAM1, ANGPT1, TIE-2, PDGFRB, CDH5, S1PR1, FGF2, Shh, TGFRB1, and Ephrin B2.
Selective binding with S1PR1 is believed to inhibit a specific subset of activated lymphocytes from migrating to sites of inflammation.
S1PR1 is one of five G protein-coupled receptors (S1PR1-5) of sphingosine-1-phosphate (S1P) (Hannun and Obeid, 2008), which is a potent lipid mediator produced from the metabolism of sphingolipid by the actions of sphingosine kinase.
Selective binding with S1PR1 is believed to inhibit a specific sub set of activated lymphocytes from migrating to sites of inflammation.
Selective binding with S1PR1 receptors is believed to inhibit a specific sub set of activated lymphocytes from migrating to sites of inflammation.