S1PR3

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S1PR3

A gene on chromosome 9q22.1-q22.2 that encodes an EDG (endothelial differentiation, G protein-coupled) receptor for sphingosine 1-phosphate, which helps regulate angiogenesis and vascular endothelial cell function.
References in periodicals archive ?
Epix") announced today that AMG 277 discriminates against S1P3 receptor by 50-fold and that the S1P1 lead compounds will be offered December 8, 2011 in a sealed bid sale.
AMG 277 has 57-nM functional EC50 for hS1P1 receptor and discriminates against S1P3 receptor by 50-fold.
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.
It is now known that S1P stimulates at least five different G-protein coupled receptors (GPCRs): S1P1, S1P2, S1P3, S1P4, and S1P5.
Epix") announced today that AMG 369 discriminates against S1P3 receptor by 296-fold and that the S1P1 lead compounds, including AMG 369, will be offered December 8, 2011 in a sealed bid sale.