S100A7

S100A7

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The function of the  S100A7-encoded protein is unknown.
 
Molecular pathology
S100A7 is overexpressed in the skin lesions of psoriasis, but is not a candidate gene for familial psoriasis.
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40,56-64) A variety of other antibodies such as cytokeratin 7, 34PE12, and S100A7 are less specific and sensitive for squamous differentiation.
A number of urinary markers are currently under investigation for early detection of SCC, including S100A7,[sup.
In preclinical mouse models of psoriasis, IMO-3100 exerted therapeutic activity by inhibiting disease-associated gene expression and cytokines, such as IL-6, IL-22, IL-17, IL-23, NLRP3 and IL-1, and proteins in the skin such as S100A7, DEFB4 and LL37.