S100A6


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S100A6

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression, differentiation and other intracellular activities. S100A6 is thought to play a role in stimulating Ca2+-dependent insulin release, stimulating prolactin secretion, and exocytosis.
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Genes of diverse functional groups and signaling routes appeared: Cytoskleleton (BCL7A, DYNC1L12, SEFT10, SEPT11), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, POLR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), cell death (CASP2, INC2, MDM4, NAIP), DNA maintenance and processing (BAHCC1, FANCA, HIST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, TICAM2), transport functions (ABCC1, FXYD2, S100A6, SCNN1C, XP05), oxidative stress response (SPATS2L, GSTT2B, NQ01), blood coagulation (FGA, MATR3, PROCR, PIK3CG), and others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
434 S100A6 S100 calcium binding Calcium sensor protein A6 0.
Detection of S100B, S100A6 and galectin-3 ligands in meningiomas as markers of aggressiveness.
The individual members of the S100 protein family show a tissue- and cell-type-specific expression pattern; for example, there are high concentrations of S100B and S100A6 in the brain (6-8).
There was no interference/cross-reactivity by the other 5100 proteins tested, including S100A6 and S100A4, which are highly expressed in brain tissue.
Increased expression of S100A6 at the invading fronts of the primary lesion and liver metastasis in patients with colorectal adenocarcinoma.