S100A13

S100A13

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. The S100A13-encoded protein plays a role in the export of proteins that lack a signal peptide, which are secreted by an alternative pathway. It is widely expressed in various tissues with high expression in thyroid gland; it is co-expressed with other family members in the nucleus and in stress fibres, suggesting a role in signal transduction.
References in periodicals archive ?
In a first step we cloned human S100B, S100Al through -A6, S100A12, and S100A13 into expression vectors for high expression in Escherichia coli and purified the recombinant proteins by ammonium sulfate precipitation, followed by [Ca.