S100A12


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S100A12

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. The S100A12-encoded protein may be involved in calcium-dependent signal transduction pathways; its regulatory effect on cytoskeletal components may modulate neutrophil activities and trigger the release of cytokines.
References in periodicals archive ?
In the absence of ELISAs specific for the monomeric forms of S100A8 and S100A9 and of a commercially available test for S100A12, we have hypothesized that mass spectrometry (MS) might be a possible approach for detecting these proteins (22).
We then incubated with a mouse secondary antibody (2 [micro]L diluted in 10 mL;GEHealthcare/Amersham Biosciences) to specifically detect S100A8 and SAA, with a rabbit secondary antibody (2 [micro]L diluted in 10 mL; Dako) to detect S100A9, or with a goat secondary antibody (2 [micro]L diluted in 10 mL; Santa Cruz Biotechnology) to detect S100A12.
S100A12 induces the expression of endothelial adhesion molecules, promoting leukocyte recruitment (33), neutrophil oxidative burst, degranulation and secretion (34), and pulmonary mast cell activation (35).