S100A10


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S100A10

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. The S100A10-encoded protein is thought to play a role in exocytosis and endocytosis.
References in periodicals archive ?
3 was depleted by FA treatment at the promoters of the genes that encode EGR2, S100A10, and H3.
Gene ID Forward primer EGR-2 (early growth response-2) 5'-CAGCGACGTCACGGGTATT-3' IAP (inhibitor of apoptosis) 5'-CCGCTGGAGTTCCCCTAAG-3' S100A10 5'-GCAGGGTCATCCAGCAAGTAA-3' MT1F 5'-TCCTGCAAGTGCAAAGAGTC-3' H3.
Several genes including genes coding proteins associated with response to microbes and phagocytosis (S100A8, S100A10, LYZ, CD 14, CD93) and processing and presentation of antigens linked to MHC class II molecules (CD74, IFI30, HLA-DR paralogues) were found to be highly expressed in intermediate monocytes as compared to non-classical monocytes.
professor in the Departments of Biochemistry and Molecular Biology and Pathology, and Canada Research Chair in Cancer Research at Dalhousie University in Nova Scotia, detailed the key role the macrophage cell surface protein S100A10 plays in allowing macrophages to move to the site of tumor growth - a process that is essential to tumor development.
The researchers found on the outside surface of the macrophage is a protein called S100A10, which enables the macrophage to remove the tissue barriers retarding migration to the tumor site.