S100A1

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S100A1

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells, and involved in regulating cell cycle progression and differentiation and other intracellular activities.
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For example, the RCC marker antigen and CD10 are preferentially expressed in proximal tubules and the corresponding clear cell RCC; S100A, claudins, and kidney-specific cadherin are preferentially expressed in distal convoluted tubules and corresponding chromophobe RCC and oncocytoma.
Six of the species present in the 10- to 13-kDa spectral cluster figure were identified as members of the S100A protein family, which are also derived from neutrophils.
The most readily detected and identifiable proteins in the BALF were DEFAs and S100A proteins.
Therefore, higher than normal concentrations of the S100A and DEFAs molecules in the CF lung likely contribute to the excessive proinflammatory environment through multiple processes, potentially inhibiting resolution of inflammation and allowing tissue damage to occur.
Each major type of renal epithelial neoplasm is thought to be derived from a specific nephron segment, and thus, is expected to display an immunoprofile akin to that of the parental nephron segment, for examples, the RCC marker (17) and CD10 for proximal tubules (22) and the corresponding clear cell and papillary RCCs; parvalbumin, (16,23,24) S100A, (25-(27) claudins, (28) kidney-specific cadherin for distal portion of the nephron, (29,30) and the corresponding chromophobe RCC and oncocytoma; and high-molecular-weight cytokeratins for the collecting duct and the corresponding collecting duct RCC.
The staining pattern is nuclear for PAX2, PAX8, and TFE3; combined nuclear and cytoplasm stain for S100A and S100P; and cytoplasmic/cell membrane stain for other markers.