Also found in: Acronyms.

S-adenosyl-l-methionine (SAM, AdoMet, SAM-e),

[0] A nutraceutical with antioxidative stress effect; may be used in management of liver disease; is a precursor of cysteine. In human medicine, may be used to scavenge free radicals associated with toxic insults to liver (e.g., alcohol, infection). During liver-function compromise, the resident enzyme system that generates SAM-e endogenously is compromised.
Synonym(s): active methionine
References in periodicals archive ?
Specific contribution of methionine and choline in nutritional nonalcoholic steato-hepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.
Biochemistry and pharmacology of S-adenosyl-L-methionine and rationale for its use in liver disease.
Role of S-adenosyl-L-methionine in the treatment of alcoholic liver disease: introduction and summary of the symposium.
S-adenosyl-L-methionine antagonizes oral contraceptive-induced bile cholesterol supersaturation in healthy women: preliminary report of a controlled randomized trial.
Pharmacodynamic studies on the central mode of action of S-adenosyl-L-methionine (SAMe) infusions in elderly subjects, utilizing EEG mapping and psychometry.
Inhibition of mouse-killing behavior by S-adenosyl-L-methionine in midbrain raphe-lesioned and olfactory-bulbectomized rats.
Influence of S-adenosyl-L-methionine on chronic mild stress-induced anhedonia in castrated rats.
S-adenosyl-L-methionine prevents 5-HT(1A) receptors up-regulation induced by acute imipramine in the frontal cortex of the rat.
SAMe is an acronym for S-adenosyl-L-methionine, a natural compound found in every human cell and involved in over 35 biochemical processes in the body.
Effect of S-adenosyl-L-methionine administration on red blood cell cysteine and glutathione levels in alcoholic patients with and without liver disease.
Anti-inflammatory and analgesic action of S-adenosyl-L-methionine (SAMe) in experimental tests on laboratory animals.
Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine.