S-adenosyl-l-methionine

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S-adenosyl-l-methionine (SAM, AdoMet, SAM-e),

(a-den'ō-sil'me-thī'ō-nēn),
[0] A nutraceutical with antioxidative stress effect; may be used in management of liver disease; is a precursor of cysteine. In human medicine, may be used to scavenge free radicals associated with toxic insults to liver (e.g., alcohol, infection). During liver-function compromise, the resident enzyme system that generates SAM-e endogenously is compromised.
Synonym(s): active methionine
References in periodicals archive ?
Effects of dietary supplementation with N-acetyl cysteine, acetyl-L-carnitine and S-adenosyl methionine on cognitive performance and aggression in normal mice and mice expressing human ApoE4.
The indispensable amino acid methionine and its metabolites are involved in multiple fundamental biological processes including protein deposition and the synthesis of S-adenosyl methionine (Finkelstein and Mudd, 1967).
The company's rapid, mix-and-measure homogeneous assays have already been adapted for the detection of a range of biologically and therapeutically important macromolecules, including cAMP, tryptophan, S-adenosyl methionine, PDE assay, biotin, insulin, C-peptide, albumin, C-reactive protein (hCRP), IgG, IgM, E.
In September, Consumer Reports published an article on Dangerous Supplements identifying S-Adenosyl Methionine (SAMe) as one of 11 supplements worth considering for certain conditions, including major depression.
31 /PRNewswire-USNewswire/ -- A new study conducted by investigators at Harvard Medical School and Massachusetts General Hospital (MGH) suggests that S-Adenosyl Methionine (SAMe), an over-the-counter dietary supplement, can be an effective, relatively well-tolerated, adjunctive treatment for adults with major depressive disorders who do not respond to their treatment with antidepressant medication.
S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial.
Arthroleve is formulated of natural compounds including s-adenosyl methionine, glucosamine sulfate and harpagophytum procumbens extract.
CLINICAL TRIAL ABSTRACT: Report Title: Oral S-Adenosyl Methionine (SAMe) for Antidepressant Augmentation: Open-label Trial Educational Objectives: Recognize the potential role of oral SAMe when used in conjunction with selective serotonin reuptake inhibitors or venlafaxine in the treatment of major depressive disorder.